My research focusses on developing novel x-ray imaging techniques to reveal features at the micron scale, and then encapsulating the insights gained into computational simulations. This includes developing nano-precision rigs that simulate the dynamic behaviour of both biological and non-biological materials on a synchrotron beamline, enabling us to see inside organs (or components) in 3D as they change in time. A key focus of his group of 40 researchers is using the ESRF-EBS to resolve features at a cellular level in intact human organs using Hierarchical Phase-Contrast Tomography (HiP-CT, see mecheng.ucl.ac.uk/hip-ct/). The results of this work are publicly available as a Human Organ Atlas with a local voxel size of ca. 1 micron, human-organ-atlas.esrf.fr.
- Fellow, Royal Academy of Engineering, 2020
- Fellow, Institute of Materials, Minerals and Mining, 2004
- Walsh, C.L., Tafforeau, P., Wagner, W.L., Jafree, D.J., Bellier, A., Werlein, C., Kühnel, M.P., Boller, E., Walker-Samuel, S., Robertus, J.L., Long, D.A., Jacob,J, Marussi, S, Brown, E, Holroyd,N, Jonigk,DD, Ackermann,M, Lee, PD, “Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography.” Nature Methods (2021). DOI: 10.1038/s41592-021-01317-x
- Madi K, Staines KA, Bay BK, Javaheri B, Geng, H, Bodey AJ, Cartmell S, Pitsillides AA, Lee PD, “In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography”, Nature Biomedical Eng., (2019), 4 (3), 343-354. DOI: 10.1038/s41551-019-0477-1
CIFAR is a registered charitable organization supported by the governments of Canada, Alberta and Quebec, as well as foundations, individuals, corporations and Canadian and international partner organizations.