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Sara Mostafavi

Appointment

Fellow

International Scientific Advisory Committee member

CIFAR Pan-Canadian Artificial Intelligence Strategy Leadership

Child & Brain Development

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Mostafavi Lab

About

Sara Mostafavi is a computational biologist who seeks to understand the interrelationship between genotype and phenotype in the context of common human clinical traits.

In particular, her interest lies in developing and applying statistical and machine learning techniques to study the genetic basis of complex diseases, by combining association evidence across multiple genome-wide data sources, such as gene expression and genotype data, and by modelling prior biological pathways and networks for disentangling spurious from meaningful correlations.

Awards

  • Ontario Graduate Scholarship, 2008–2010
  • Queen’s Graduate Scholarship, 2004–2006

Relevant Publications

  • Mostafavi, S. et al. “Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing.” Mol. Psychiatry 19, no. 12 (December 2014): 1267–1274.

  • Mostafavi, S. et al. “Variation and genetic control of gene expression in primary immunocytes across inbred mouse strain.” J. Immunol. 193, no. 9 (November 2014): 4485–4496.

  • Battle, A. et al. “Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals.” Genome Res. 24, no. 1 (January 2014): 14–24.

  • Ardlie, K.G. et al. “Sharing and Specificity of Co-expression Networks across 35 Human Tissues.” PLoS Comput. Biol. 11, no. 5 (May 2013): e10042220.

  • Mostafavi, S., and Q. Morris. “Combining many interaction networks to predict gene function and analyze gene lists.” Proteomics 12, no. 10 (May 2012): 1687–1696.

Institution

University of Washington

Department

Allen School of Computer Science and Engineering

Education

  • PhD (Computational Biology), University of Toronto
  • MSc (Computational Biology and Bioinformatics), Queen's University
  • BSc Honors (Computer Science, Life Sciences), University of Toronto

Country

United States

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