Ann C. Gregory
Appointment
CIFAR Azrieli Global Scholars 2024-2026
CIFAR MacMillan Multiscale Human
About
My research explores the human virome, the vast collection of viruses residing within and on our bodies. Using both computational and experimental approaches, we aim to unravel how these viruses interact with our immune system and other microbes, and how they influence our health. Computationally, my lab is leveraging advanced technology to identify new viruses based on their 3D structures and map viral interactions across the human body to understand their distribution and impact. Experimentally, my lab is isolating gut viruses to develop personalized phage therapies for gut-related diseases. My lab aims to advance virus discovery and pave the way for novel therapeutic strategies using viruses.
Awards
- EMBO Long-Term Postdoctoral Fellowship, 2019-2022
- NIH T32 Pre-doctoral Fellowship, 2017-2018
Relevant Publications
- Gregory, A. C., Zablocki, O., Zayed, A. A., Howell, A., Bolduc, B., & Sullivan, M. B. (2020). The gut virome database reveals age-dependent patterns of virome diversity in the human gut. Cell host & microbe, 28(5), 724-740.
- Gregory, A. C., Zayed, A. A., Conceição-Neto, N., Temperton, B., Bolduc, B., Alberti, A., ... & Roux, S. (2019). Marine DNA viral macro-and microdiversity from pole to pole. Cell, 177(5), 1109-1123.
- Kang, D. W., Adams, J. B., Gregory, A. C., Borody, T., Chittick, L., Fasano, A., ... & Krajmalnik-Brown, R. (2017). Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome, 5, 1-16.