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Christina A. Cuomo

Appointment

  • Fellow
  • Fungal Kingdom: Threats & Opportunities

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About

Christina Cuomo is a senior group leader at the Broad Institute of MIT and Harvard whose research group uses genomic methods to characterize the evolution of fungal pathogens.

She incorporates the latest innovations in sequencing technology and computational approaches into her work and sets the standard for the production and analysis of fungal genomes.

Studying species across the fungal kingdom, she has produced major insights into the unique features of pathogenic species, how genomes evolve, variation with pathogen populations and genes involved in host interaction. Her work is highly collaborative, engaging a global network of computational biologists, experimental scientists, clinicians and field researchers.

Relevant Publications

  • Muñoz JF, Gade L, Chow NA, Loparev VN, Juieng P, Farrer RA, Litvintseva AP, Cuomo CA. 2018. Genomic insights into multidrug-resistance, mating, and virulence in Candida auris and related emerging species. Nature Communications 9(1):5346.
  • Desjardins CA, Giamberardino C, Sykes SM, Yu CH, Tenor JL, Chen Y, Yang T, Jones AM, Sun S, Haverkamp MR, Heitman J, Litvintseva AP, Perfect JR, Cuomo CA. 2017. Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans. Genome Research 27(7):1207-1219.
  • Cuomo CA, Desjardins CA, Bakowski MA, Goldberg J, Ma AT, Becnel JJ, Didier ES, Fan L, Heiman DI, Levin JZ, Young S, Zeng Q, Troemel ER. 2012. Microsporidia genome analysis reveals evolutionary strategies for obligate intracellular growth. Genome Research, 22(12): 2478-88.
  • Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PW, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KA, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MP, Sudbery PE, Srikantha T, Zeng Q, Berman J, Berriman M, Heitman J, Gow NA, Lorenz MC, Birren BW, Kellis M, Cuomo CA. 2009. Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459:657-62.
  • Cuomo CA, Guldener U, Xu JR, Trail F, Turgeon BG Di Pietro A, Walton JD, Ma LJ, Baker SE, Rep M, Adam G, Antoniw J, Baldwin T, Calvo S, Chang YL, Decaprio D, Gale LR, Gnerre S, Goswami RS, Hammond-Kosack K, Harris LJ, Hilburn K, Kennell JC, Kroken S, Magnuson JK, Mannhaupt G, Mauceli E, Mewes HW, Mitterbauer R, Muehlbauer G, Münsterkötter M, Nelson D, O'donnell K, Ouellet T, Qi W, Quesneville H, Roncero MI, Seong KY, Tetko IV, Urban M, Waalwijk C, Ward TJ, Yao J, Birren BW, Kistler HC. 2007. 2007. The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. Science 317: 1400-2.

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