Iliyan Iliev’ s pioneering research on the gut mycobiota defined a role of commensal fungi in innate mucosal and protective humoral immunity and provided evidence for mycobiota involvement in the pathophysiology of Inflammatory Bowel Disease (IBD). The laboratory applies translational, experimental and computational approaches to study the role of immunity to mycobiota early and later in life, upon therapeutic interventions and during conditions, such as inflammatory bowel disease, allergy, gastrointestinal cancers and immunodeficiencies, where fungi contribute to pathologies. Current effort in the laboratory, focused on the gut-bran axis, explores the unique neuro-modulatory properties of fungi.
- Burroughs Welcome Fund Investigator in the Pathogenesis of Infectious Disease
- Cancer Research Institute Lloyd J. Old STAR Fellow
- Young Investigator Award from the Society for Mucosal Immunology
- Irma T. Hirschl Scholar
- Kenneth Rainin Foundation Innovator Award
- Li XV, Leonardi I, Putzel, G., Doron I, Fiers WD, Semon A, Bialt-DeCelie M, Gao IH, Lin WY, Naglik J, Hube B, Scherl E, Iliev ID (2022), Immune regulation by fungal strain diversity in inflammatory bowel disease; Nature 603, 672–678, doi: 10.1038/s41586-022-04502-w
- Leonardi I, Li X, Semon A, Li D, Doron I, Putzel G, Bar A, Prieto D, Rescigno M, McGovern DPB, Pla J, Iliev ID.(2018), CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi. Science , 359 (6372): 232-236. DOI: 10.1126/science.aao1503
- Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DPB, Brown GD, Underhill DM (2012), Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science 336(6086):1314-7. DOI: 10.1126/science.1221789
CIFAR is a registered charitable organization supported by the governments of Canada, Alberta and Quebec, as well as foundations, individuals, corporations and Canadian and international partner organizations.