Muzlifah Haniffa
About
My research is focused on studying human development primarily the developing human immune system and skin to inform stem cell therapy, tissue engineering and adult pathology. My team leverages cutting edge single cell genomics, computation, stem cell culture systems including the generation of skin organoids as experimental models to study human development. I play a leading role in the Human Developmental Cell Atlas and a member of the Human Developmental Biology Initiative. My research is also focused on personalised therapy including target discovery for immune-mediated inflammatory diseases primarily focused on skin.
Awards
- Fellow, Academy of Medical Sciences, 2020
- Foulkes Foundation Medal, Academy of Medical Sciences, 2019
- ACTERIA Prize, European Federation of Immunological Societies, 2018
- LEO Pharma Silver Prize, European Society for Dermatology Research, 2013
- Young Investigator Award, British Society for Investigative Dermatology, 2012
Relevant Publications
- Popescu DM*, Botting RA*, Stephenson E*, Green K, Webb S, Jardine L, Calderbank EF, Polanski K, Goh I, Efremova M, Acres M, Maunder D, Vegh P, Gitton Y, Park JE, Vento-Tormo R, Miao Z, Dixon D, Rowell R, McDonald D, Fletcher J, Poyner E, Reynolds G, Mather M, Moldovan C, Mamanova L, Greig F, Young MD, Meyer KB, Lisgo S, Bacardit J, Fuller A, Millar B, Innes B, Lindsay S, Stubbington MJT, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Filby A, Carey P, Villani AC, Roy A, Regev A, Chédotal A, Roberts I, Göttgens B, Behjati S†, Laurenti E†, Teichmann SA†, Haniffa M†. Decoding human fetal liver haematopoiesis. Nature. 2019 Oct;574(7778):365-371. doi: 10.1038/s41586-019-1652-y
- Reynolds G*, Vegh P*, Fletcher J*, Poyner EFM*, Stephenson E, Goh I, Botting RA, Huang N, Olabi B, Dubois A, Dixon D, Green K, Maunder D, Engelbert J, Efremova M, Polański K, Jardine L, Jones C, Ness T, Horsfall D, McGrath J, Carey C, Popescu DM, Webb S, Wang XN, Sayer B, Park JE, Negri VA, Belokhvostova D, Lynch MD, McDonald D, Filby A, Hagai T, Meyer KB, Husain A, Coxhead J, Vento-Tormo R, Behjati S, Lisgo S, Villani AC, Bacardit J, Jones PH, O'Toole EA, Ogg GS, Rajan N, Reynolds NJ, Teichmann SA†, Watt FM†, Haniffa M†. Developmental cell programs are co-opted in inflammatory skin disease. Science. 2021 Jan 22;371(6527):eaba6500. doi: 10.1126/science.aba6500
- Stephenson E*, Reynolds G*, Botting RA*, Calero-Nieto FJ*, Morgan MD*, Tuong* ZK, Bach K, Sungnak W, Worlock KB, Yoshida M, Kumasaka N, Kania K, Engelbert J, Olabi B, Spegarova JS, Wilson NK, Mende N, Jardine L, Gardner LCS, Goh I, Horsfall D, McGrath J, Webb S, Mather MW, Lindeboom RGH, Dann E, Huang N, Polanski K, Prigmore E, Gothe F, Scott J, Payne RP, Baker KF, Hanrath AT, Schim van der Loeff ICD, Barr AS, Sanchez-Gonzalez A, Bergamaschi L, Mescia F, Barnes JL, Kilich E, de Wilton A, Saigal A, Saleh A, Janes SM, Smith CM, Gopee N, Wilson C, Coupland P, Coxhead JM, Kiselev VY, van Dongen S, Bacardit J, King HW; Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Rostron AJ, Simpson AJ, Hambleton S, Laurenti E, Lyons PA, Meyer KB, Nikolić MZ, Duncan CJA, Smith KGC, Teichmann SA†, Clatworthy MR†, Marioni JC†, Göttgens B†, Haniffa M†. Single-cell multi-omics analysis of the immune response in COVID-19. Nat Med. 2021 May;27(5):904-916. doi: 10.1038/s41591-021-01329-2