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Nozomu-Yachie_bw

Nozomu Yachie

Appointment

Fellow

CIFAR MacMillan Multiscale Human

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About

In current biology, our analyses of complex biological objects are limited to the time of observation. High-resolution molecular snapshots of cells can be obtained by various genomics and single-cell genomics technologies, but these technologies all require the destruction of samples, precluding the analysis of the dynamics of animals. To overcome this issue, we are developing DNA event recording systems by which molecular and cellular information within individual cells of a multicellular organism is progressively stored in cell-embedded synthetic DNA tapes. Such a system allows the readout of historical molecular expression profiles of many cells using high-throughput single-cell sequencing. Harnessing synthetic biology, genome engineering, cell engineering, and computational approaches, we develop “sensor, ” “writer,” “memory,” and “reader” systems for the video recorder of the cell.

Awards

  • Allen Distinguished Investigator, Allen Institute, 2022
  • Canada Research Chair in Synthetic Biology, Canadian Institute of Health Research, 2020
  • Minister’s Young Scientists Award, Ministry of Education and Science, Japan, 2020
  • PRESTO Researchership, Japan Science and Technology Agency (JST) 2014
  • Banting Postdoctoral Fellowship, National Sciences and Engineering Research Council of Canada, 2012

Relevant Publications

  • Masuyama, N., Konno, N. & Yachie, N. (2022) Molecular recorders to track cellular events. Science 377, 469-470. DOI: 10.1126/science.abo3471
  • Konno, N., Kijima, Y., Watano, K., Ishiguro, S., Ono, K., Tanaka, M., Mori, H., Masuyama, N., Pratt, D., Ideker, T., Iwasaki, W. & Yachie, N. (2022) Deep distributed computing to reconstruct extremely large lineage trees. Nature Biotechnology 40, 566–575. DOI: 10.1038/s41587-021-01111-2
  • Sakata, R.C., Ishiguro, S., Mori, H., Tanaka, M., Tastuno, K., Ueda, H., Yamamoto, S., Seki, M., Masuyama, N., Nishida, K., Nishimasu, H., Arakawa, K., Kondo, A., Nureki, O., Tomita, M., Aburatani, H. & Yachie, N. (2020) Base editors for simultaneous introduction of C-to-T and A-to-G mutations. Nature Biotechnology 38, 865-869. DOI: 10.1038/s41587-020-0509-0

Institution

Osaka University

University of British Columbia

University of Tokyo

Department

School of Biomedical Engineering, Premium Research Institute for Human Metaverse Medicine (PRIMe), Research Center for Advanced Science and Technology

Education

  • PhD (Systems Biology), Keio University
  • MMG (Bioinformatics), Keio University
  • BA (Environmental Information), Keio University

Country

Canada

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The Canadian Institute for Advanced Research (CIFAR) is a globally influential research organization proudly based in Canada. We mobilize the world’s most brilliant people across disciplines and at all career stages to advance transformative knowledge and solve humanity’s biggest problems, together. We are supported by the governments of Canada, Alberta and Québec, as well as Canadian and international foundations, individuals, corporations and partner organizations.

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