Chemist Sihyun Ham aims to understand why and how a normal cell becomes a disease cell at a molecular-level by using theoretical and computational methods.
The main research effort is to develop and apply innovative computational methods for elucidating the mechanisms and driving factors of biomolecular interactions related to human diseases and cellular functions. These tools and new paradigm provide a unified view on how biomolecules operate and are applied to design a new function of specific interest in cellular networks.
- Fellow of the Royal Society of Chemistry, 2016
- Scientist of the Month Award from the Korean Government, 2016
- Female Scientists of the Year Award from the Korean Government, 2014
- Distinguished Lectureship Award, Chemical Society of Japan, 2009
- Excellence in Research Award, Sookmyung Women’s University 2009–17
Chong, S-H., P. Chatterjee, and S. Ham. “Computer Simulations of Intrinsically Disordered Proteins.” Annu. Rev. Phys. Chem. 68 (2017): 117–34.
Fujiwara, D. et al. “A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Inhibitors of Intracellular Protein–Protein Interactions by Epitope and Arginine Grafting.” Angew. Chem.-Int. Edit. 55, no. 36 (2016): 10612–10615.
Teoh, C.L. et al. “Chemical Fluorescent Probe for Detection of Aβ Oligomers.” J. Am. Chem. Soc. 137, no. 42 (2015): 13503–13509.
Chong, S-H., and S. Ham. “Distinct Role of Hydration Water in Protein Misfolding and Aggregation Revealed by Fluctuating Thermodynamics Analysis.” Accounts Chem. Res. 48, no. 4 (2015): 956–65.
Chong, S-H., and S. Ham. “Interaction with the Surrounding Water Plays a Key Role in Determining the Aggregation Propensity of Proteins.” Angew. Chem.-Int. Edit. 53, no. 15 (2014): 3961–3964.
CIFAR is a registered charitable organization supported by the governments of Canada, Alberta and Quebec, as well as foundations, individuals, corporations and Canadian and international partner organizations.